The study Modelling of Energy-Climate Prospective Scenarios for the European Union for 2050 is based on the development of five long-term scenarios: a reference scenario reproducing that of the European Commission (EU Reference Scenario 2016), and four Carbon-Neutrality Scenarios (CNS). For each of them, detailed modelling was undertaken on the energy, agriculture and land use sectors, as well as the macroeconomic consequences. A sequence of models has been used to quantify and assess these scenarios: the POLES model for the energy system, the MOSUT model for agriculture, forestry and land use and the NEMESIS model for macro and sector economic aspects.